> At a Glance
> – Pennsylvania’s free Naloxone program reversed 9,500 overdoses in the first nine months of 2025
> – Nearly 800,000 naloxone doses and 737,000 test strips went to residents
> – Philadelphia is on pace for its lowest fatal-overdose total in almost 10 years
> – Why it matters: The state now records its lowest overdose death rate in a decade, showing rapid, low-cost distribution can immediately save lives
Pennsylvania’s year-old Overdose Prevention Program is delivering dramatic results: thousands of residents survived overdoses, and the state is logging its fewest drug-related deaths in ten years.
How the “Hub and Spoke” Model Works
The Shapiro Administration set up a supply chain that moves antidote kits from state caches straight to neighborhood hotspots.
Regional prevention partners act as hubs, storing naloxone and fentanyl/xylazine test strips. They pass supplies to local spokes-community groups, outreach teams, treatment centers, and corner service providers-who hand the products to people who use drugs, family members, and first-line helpers.
City-Level Impact in Philadelphia
Philadelphia is on track to post its lowest number of deadly overdoses since 2015. Five city organizations handle the bulk of in-town distribution:
- Pa. Harm Reduction Network
- Philadelphia Department of Public Health
- Philadelphia Single County Authority
- Prevention Point Philadelphia
- Savage Sisters
Key Takeaways
- 9,500-plus Pennsylvanians reversed overdoses with free naloxone between January and September 2025
- A simple hub-and-spoke logistics model moved nearly 1.6 million harm-reduction items into communities in a single year
- Philadelphia’s overdose fatality rate is falling to a ten-year low
- Anyone needing recovery support can call the PA Get Help Now helpline at 1-800-662-HELP (4357)
The surge in freely available naloxone is translating directly into fewer fatal overdoses across the Commonwealth.
