In a dramatic Week 16 Monday Night Football showdown, the San Francisco 49ers defeated the Indianapolis Colts 48-27 on the road, bringing their record to 11-4 and inching toward a historic 50-0 season.
Game Summary
The 49ers’ victory hinged on a pair of defensive plays in the fourth quarter. Philip Rivers’ pick-six moments just after a rare Brock Purdy error sealed the outcome. The Colts, now 8-7, suffered two straight losses since Rivers’ return from retirement.
Brock Purdy’s Career-Best Performance
Purdy completed 25 of 34 passes for 295 yards, five touchdowns and a pick, setting a career high in passing yards. His efficient play helped the 49ers secure the win and maintain a tight race for the NFC’s No. 1 seed.
Key Offensive Contributors

- George Kittle led all receivers with seven catches on eight targets for 115 yards and a touchdown, though he left the game with an ankle injury.
- Christian McCaffrey ran for 117 yards on 21 carries, including a season-high 24-yard run, and added two receiving touchdowns on six catches for 29 yards.
- Jonathan Taylor was held to 46 rushing yards on 16 carries and a single goal-line touchdown, a 2.9-yard average that underscored the Colts’ run-defense struggles.
Colts’ Season Outlook
The Colts, now 8-7, remain mathematically alive but face the Jacksonville Jaguars and Houston Texans, the two teams above them in the AFC South. Their season may be all but finished, especially after the loss to the 49ers.
Coaching Impact
Kyle Shanahan’s leadership has kept the 49ers in control of their destiny for the No. 1 seed. With a record of 11-4, the team must win out at home against the Chicago Bears and Seattle Seahawks in Week 17 to secure the top spot.
Key Takeaways
- Brock Purdy’s 295-yard, five-touchdown performance pushed the 49ers toward a 50-0 season.
- The Colts’ offense, led by Jonathan Taylor, was stifled on the ground and struggled to keep pace.
- The 49ers’ defensive plays in the fourth quarter sealed a 48-27 victory on Monday Night Football.
The game underscored the 49ers’ resilience amid injury challenges and set the stage for a final push to clinch the NFC’s No. 1 seed.

